Oral dosage form has the short transit time of approximately 12 hrs through GIT. In intravenous drug delivery, the duration of drug action is short. In topical drug delivery, percutaneous absorption of most drugs is limited due to highly impermeable stratum -corneum. Implantable drug delivery devices are devoid of limitations associated with oral, intravenous, topical drug administration. Implantable delivery have advantages like Potential for controlled release, intermittent release, bio-responsive release Improved drug delivery. Osmotic pump, implant Ceramic composite system, Intraocular implant, Intrauterine implant, Transurethral implant are some of the examples of implantable delivery. Newer technologies include DURIN biodegradable implant technology which uses the biodegradable polyester excipients and have features like Superior delivery kinetics, Superior drug loading & stability, Fully biodegradable, History of safe use and Cost effective. ATRIGEL drug delivery technology consists of biodegradable polymers in biocompatible carrier. Atrigel system is somewhat viscous polymer solution, so currently marketed products available in pre-filled plastic syringes. Other technology is ALZAMER DEPOT TECHNOLOGY offers sustained delivery of therapeutic agents, including proteins, peptides, and other bio-molecules for up to a month with minimal initial drug burst & bio-erosion of the dosage form. SABER DEPOT TECHNOLOGY uses a high viscosity carrier such as sucrose acetate isobutyrate (SAIB), solvent. REGEL depot technology, IMPLANTABLE PUMP, PERISTALTIC PUMP, MEMS based IDD TECHNOLOGY, MICROCHIP DRUG DELIVERY DEVICE are some of the example of the newer technologies of implantable drug delivery.
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